Piece-Linear Aggregates for Formai Specification and Simulation of Hybrid Systems: Pharmacokinetics Patient-Controlled Analgesia

Abstract

Piece Linear Aggregates formalism (PLA) for specification and simulation of hybrid systems, when continuous components are described in ordinary differential equations (ODEs). PLA is used to create Quantized State System (QSS) model. QSS is integration based method, created for ODE solving. Since QSS method first was introduced for use in Discreet Event Systems (DEVS) formalism, we adapted it for PLA formalism, which is fundamentally consanguineous to DEVS formalism. Pharmacokinetics model is used as example of hybrid system. Pharmacokinetics is a branch of pharmacology which describes administered drug absorption and distribution in human body. In pharmacokinetics drug distribution is described using ODE. In order to use drug injection in pharmacokinetics model, we have to modify standard QSS model and add some specific capabilities. Result: modified QSS method was obtained and used for pharmacokinetic model specification. Simulation of morphine concentration in plasma was performed using real pharmacokinetics data to test Patient-Controlled Analgesia (PCA) method effectiveness. Ill. 2, bibl. 6 (in English; abstracts in English and Lithuanian).

http://dx.doi.org/10.5755/j01.eee.110.4.293