Markovian Model of the Voltage Gating of Connexin-based Gap Junction Channels

  • A. Sakalauskaite Kaunas University of Technology
  • H. Pranevicius Kaunas University of Technology
  • M. Pranevicius Albert Einstein College of Medicine
  • F. Bukauskas Albert Einstein College of Medicine
Keywords: Kaunas University of Technology, Albert Einstein College of Medicine


Gap junction (GJ) channels, which are formed of a connexin (Cx) protein provide pathways through which ions and small molecules are exchanged between adjacent cells. GJs co-ordinate the cellular activity in tissues by synchronizing their electrical activity and allowing a direct cell-to-cell chemical signaling. Electrically gap junctions present nonlinear conductance that depends on transjunctional voltage and can be modulated by chemical reagents and ions, such as pH, Ca2+, etc. Here, we describe the model of the voltage gating of gap junctions using Markovian formalism. The results obtained using a stationary Markov model are well comparable with those obtained using a stochastic/imitational model of voltage gating. Ill. 5, bibl. 5, tabl. 3 (in English; abstracts in English and Lithuanian).