Design and Optimization of Pulsed Magnetic Field Generator for Cell Magneto-Permeabilization

Vitalij Novickij, Audrius Grainys, Gediminas Staigvila, Sonata Tolvaisiene, Tomas Ustinavicius, Jurij Novickij

Abstract


Biological cell magneto-permeabilization is the phenomenon when the membrane of the cell increases permeability to molecules to which it was initially impermeable due to the exposure to high pulsed magnetic fields. Flexible high power electronics systems are required for triggering this effect. In this work, we have designed a high power (938 A, 2 kV) pulsed magnetic field generator (up to 5.5 T), which generates 10 μs–100 μs pulses with predefined repetition frequency of 1 Hz–100 Hz. We have applied SPICE and COMSOL Multiphysics modelling for design and development of the system, which showed a good agreement with the experimental results. The snubber and crowbar circuitry has been implemented for compensation and dampening of the transient processes on the switches, which allowed limiting the overvoltage to 0.25 kV. The multilayer inductor structure and design considerations are also presented in the study.

DOI: http://dx.doi.org/10.5755/j01.eie.23.2.17994


Keywords


Pulsed power; transient process; magnetoporation; inductor

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Print ISSN: 1392-1215
Online ISSN: 2029-5731